As bases de Schiff est�o entre os ligandos mais importantes devido � sua capacidade quelante e �s suas diversas aplica��es nos dom�nios medicinal e farmacol�gico. Nos �ltimos anos, os investigadores t�m-se debru�ado extensivamente sobre a qu�mica de coordena��o e a reatividade dos ligandos de bases de Schiff. A coordena��o de ligandos de base de Schiff com i�es met�licos � particularmente interessante porque estes ligandos demonstraram propriedades biol�gicas melhoradas ap�s metala� ...
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As bases de Schiff est�o entre os ligandos mais importantes devido � sua capacidade quelante e �s suas diversas aplica��es nos dom�nios medicinal e farmacol�gico. Nos �ltimos anos, os investigadores t�m-se debru�ado extensivamente sobre a qu�mica de coordena��o e a reatividade dos ligandos de bases de Schiff. A coordena��o de ligandos de base de Schiff com i�es met�licos � particularmente interessante porque estes ligandos demonstraram propriedades biol�gicas melhoradas ap�s metala��o. � bem conhecido que os �tomos dadores de azoto e oxig�nio nos ligandos de base de Schiff desempenham um papel decisivo na coordena��o de metais nos locais activos de numerosas metalobiomol�culas. A combina��o de bases de Schiff com i�es met�licos em complexos met�licos tem demonstrado actividades biol�gicas frutuosas, incluindo propriedades antitumorais, anti-amo�bicas, antimicrobianas e anti-inflamat�rias. Os complexos de metais de transi��o de bases de Schiff exibem diferentes estados de oxida��o e podem interagir com v�rias biomol�culas carregadas negativamente, tornando este um campo sempre verde na qu�mica bioinorg�nica.
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