La physaline B (C28H32O9), principale physaline active de Physalis angulata L, a �t� isol�e � partir de la plante enti�re de Physalis angulata L et caract�ris�e par une analyse de diffraction des rayons X. Elle cristallise dans le syst�me monoclinique, groupe spatial P2(1) avec C28H32O9, a = 12.4996(2), b = 14.35620(10), c = 14.75190(10)�, V = 2607.97(5)�3, Z = 4, Dc = 1.382mg/cm3, Mr = 542.56, F(000) = 1152, et = 0.870 mm-1. Le R final = 0,0389 et wR = 0,1037 pour 47670 r�flexions observ�es (I > 2 ...
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La physaline B (C28H32O9), principale physaline active de Physalis angulata L, a �t� isol�e � partir de la plante enti�re de Physalis angulata L et caract�ris�e par une analyse de diffraction des rayons X. Elle cristallise dans le syst�me monoclinique, groupe spatial P2(1) avec C28H32O9, a = 12.4996(2), b = 14.35620(10), c = 14.75190(10)�, V = 2607.97(5)�3, Z = 4, Dc = 1.382mg/cm3, Mr = 542.56, F(000) = 1152, et = 0.870 mm-1. Le R final = 0,0389 et wR = 0,1037 pour 47670 r�flexions observ�es (I > 2 (I)). La mol�cule rigide est constitu�e de huit anneaux fusionn�s impliquant deux lactones. Il y a deux mol�cules C28H32O9 dans une unit� sym�trique, et le compos� titre est empil� dans une structure de couche 3D gr�ce � des liaisons hydrog�ne.Dans la plage de 5-20 mol/L, la physaline B peut inhiber de mani�re significative la s�cr�tion des cytokines inflammatoires TNF- et IL-6 sur les cellules RAW264.7. Les r�sultats sugg�rent que la physaline B a une activit� anti-inflammatoire in vitro.
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