This revised and updated text on diabetes mellitus encompasses recent advances in molecular and cellular findings, and provides new therapeutic modalities for the disease. Adhering to the successful format of the first edition, the book is divided into ten distinct sections, each containing individual chapters that progress from basic mechanisms to physiology to therapeutic. It covers the complications of diabetes at both the basic and clinical levels. New chapters include the importance of the characterization and cloning ...
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This revised and updated text on diabetes mellitus encompasses recent advances in molecular and cellular findings, and provides new therapeutic modalities for the disease. Adhering to the successful format of the first edition, the book is divided into ten distinct sections, each containing individual chapters that progress from basic mechanisms to physiology to therapeutic. It covers the complications of diabetes at both the basic and clinical levels. New chapters include the importance of the characterization and cloning of sulfonylurea receptors, the role of lipids and its relationship to glucotoxicity, and the effects of GLP-1 during insulin secretion. Other coverage includes updates on such topics as: the identification of "diabetes genes"; prevention and treatment of type I and type II diabetes; the role of GLP-1 and IRS-1 during insulin signalling; engineering of the pancreatic cell; principles of lipotoxicity and glucotoxicity; the role of adipose tissue in the pathogenesis of insulin resistance associated with obesity; and diet therapy and its effects on the treatment of type I and type II diabetes.
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