This text brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T-cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T-cell activation, and the role of apoptosis in tolerance. Consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T-cell activation during tumour therapy, anti-antigen specific immune ...
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This text brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T-cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T-cell activation, and the role of apoptosis in tolerance. Consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T-cell activation during tumour therapy, anti-antigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.
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