Studies of receptors, ion channels, and other membrance proteins reuire a solid understanding of their structural principles. Membrane protein structure, however, is one of the most challenging fields of structural biology. The structures of only three types of transmembrance proteins have been determined to moderate or high resolution during a two-decade period in which the amino acid sequence of hundreds, if not thousands, of membrane proteins have been reported. As a result, the creation of hypothetical structural models ...
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Studies of receptors, ion channels, and other membrance proteins reuire a solid understanding of their structural principles. Membrane protein structure, however, is one of the most challenging fields of structural biology. The structures of only three types of transmembrance proteins have been determined to moderate or high resolution during a two-decade period in which the amino acid sequence of hundreds, if not thousands, of membrane proteins have been reported. As a result, the creation of hypothetical structural models to serve as guides for studies of receptors, channels, and other membrance proteins has become crucially important to progress. But the development of suitable models requires an understanding of protein structure and structure-prediction methods as well as membrane biophysics and lipid physical chemsitry. Because the literature in each of these fields is expanding rapidly and can be daunting even for the experts, this book has been organized to share the experiences of some of the experts with researchers who need to know about the critical issues of membrane protein strcture. This book is intended for physiologists, biophysicists, biochemists, cell biologists.
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Near Fine. 0195071123. Methods In Physiology Series Series; B&W Illustrations; 9.1 X 6.6 X 1.1 inches; x, 395 pages; Hard cover is wheat colored boards with black lettering. NEW book. Pages are clean and tight. Illustrated with b/w figures. Contains 16 essays, by various authors. This monograph explores the creation of hypothetical structure models to serve as guides for the study of membrane proteins. The text covers biochemical and molecular biological approaches, direct structural methods and model, and physiochemical approaches. Index.
