Provides practical approaches for informatics, big data, and complex data sets of cellular signal transduction in toxicology and pharmacology This book offers a thorough discussion of signal transduction mechanisms and approaches that can help toxicologists and pharmacologists guide future study design and data interpretation. It gives readers a solid background in signal transduction networks, while supplying the tools necessary for further research in this expanding area. These tools include a discussion of experimental ...
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Provides practical approaches for informatics, big data, and complex data sets of cellular signal transduction in toxicology and pharmacology This book offers a thorough discussion of signal transduction mechanisms and approaches that can help toxicologists and pharmacologists guide future study design and data interpretation. It gives readers a solid background in signal transduction networks, while supplying the tools necessary for further research in this expanding area. These tools include a discussion of experimental design, sample handling, analytical measurement techniques, and data analysis and interpretation (including novel modeling approaches). Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation is organized hierarchically. The first four chapters describe the architecture of signaling networks--from a physical basis of understanding signaling through mechanisms, physiological response, and human disease. The last half of the book is a how-to for incorporating signal transduction research into your portfolio--from designing signal transduction studies, to measuring and monitoring signaling responses, interpreting and transforming data into useable information, and finally outlining critical future needs in signal transduction research. Covers a topic of key interest to toxicologists as there is a growing body of research into the role of signaling mechanisms in toxicology Features a practical focus on modern approaches like the use of informatics, big data, and complex data sets Combines fundamentals/basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques Written for an audience with a background in biochemistry or cell biology, Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation provides a comprehensive understanding of signal transduction research that is applicable to industry, academia, and government.
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