Excerpt from The Journal of Laboratory and Clinical Medicine, Vol. 2: October, 1916-September, 1917 The clinical findings in regard to uric acid in human blood are of consider able interest. The field of work here is new and we must be cautious in draw ing conclusions. The recent researches of Folin and his pupils in Boston and of Myers and Fine at the post-graduate School in New York have Shown that normal human blood contains from one to three milligrams of uric acid in 100 grams of blood. In lead poisoning, in gout, and ...
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Excerpt from The Journal of Laboratory and Clinical Medicine, Vol. 2: October, 1916-September, 1917 The clinical findings in regard to uric acid in human blood are of consider able interest. The field of work here is new and we must be cautious in draw ing conclusions. The recent researches of Folin and his pupils in Boston and of Myers and Fine at the post-graduate School in New York have Shown that normal human blood contains from one to three milligrams of uric acid in 100 grams of blood. In lead poisoning, in gout, and in nephritis, the uric acid con tent of the blood is usually markedly increased and the determination of uric acid in the blood of suspected gout is of unquestioned value. In connection with gout the recent research-es have shown that the old idea that in this condition the blood becomes saturated with uric acid must be abandoned. The solubility of uric acid in blood serum has been Shown to be much greater than the concentration of uric acid occurring in the blood of gout. Furthermore, in nephritis the uric acid content of the blood may be quite as high as in gout for long periods of time without any symptom of uric acid deposition occurring. We have therefore to assume that in gout there is not only' a kidney deficiency for uric acid elimination but that there is also a direct vicarious ex cretion of uric acid from the blood stream into certain tissues where it finally reaches the saturation point and deposits in the form of sodium acid urate. The view of Minkowski and others that the uric acid circulates in gout in some dif ferent form from that in the normal, finds some support from the results al ready referred to with the blood of lower mammals. It is my opinion that this view will prove to be the correct one. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at ... This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
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