This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1899 edition. Excerpt: ...directly to the inferior vena cava. Under these circumstances the liver receives blood only by the hepatic artery. The amount of urea is lessened, and its place is taken by ammonia. 3. When degenerative changes occur in the liver, as in cirrhosis of that organ, the urea formed is much lessened, and its ...
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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1899 edition. Excerpt: ...directly to the inferior vena cava. Under these circumstances the liver receives blood only by the hepatic artery. The amount of urea is lessened, and its place is taken by ammonia. 3. When degenerative changes occur in the liver, as in cirrhosis of that organ, the urea formed is much lessened, and its place is taken by ammonia. In acute yelloiu atrophy urea is almost absent in the urine, and, again, there is considerable increase in the ammonia. In this disease leucine and tyrosine are also found in the urine; undue stress should not be laid upon this latter fact, for the small amounts of leucine and tyrosine found doubtless originate in the intestine, and, escaping further decomposition in the degenerated liver, pass as such into the urine. We have to consider next the intermediate stages between proteid and urea. A few years ago Drechsel succeeded in artificially producing urea from casein. More recent work has shown that this is true for other proteids also. If a proteid is decomposed by hydrochloric acid, a little stannous chloride being added to prevent oxidation, a number of products are obtained, such as ammonium salts, leucine, tyrosine, aspartic and ghitaminic acids. This was known before, so the chief interest centres round two new substances, precipitable by phosphotungstic acid. One of these is called lysine (C6HHN202, probably di-amido-eaproic acid); the other was first called lysatinine. Hedin then showed that lysatinine is a mixture of lysine with another base called arginine (C6H14N402); it is from the arginine that the urea comes in the experiment to be next described. Arguing from some resemblances between this substance and creatine, Drechsel expected to be able to obtain urea from it, and his expectation was confirmed...
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