This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1886 Excerpt: ... day. In all these animals we found, on anatomical examination, severe double pleurisy, with more or less turbid, purulent fluid to the amount of several ccm., also turbid, purulent fluid in the pericardium. The lungs were deep red and cedematous. In three cases there were no further changes, but in three others there ...
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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1886 Excerpt: ... day. In all these animals we found, on anatomical examination, severe double pleurisy, with more or less turbid, purulent fluid to the amount of several ccm., also turbid, purulent fluid in the pericardium. The lungs were deep red and cedematous. In three cases there were no further changes, but in three others there was lobular, red, grey or reddish-grey infiltration at the parts of the lobes removed from the hilus. The five other guinea-pigs showed no definite evidence of disease. Two of them were killed on the third day after injection, and showed only a few clear drops of fluid, without micrococci, in the pleural cavity; on inoculation of this fluid into jelly no growth occurred. On the contrary, the pleuritic fluid of the animals which became ill or died contained numbers of micrococci with capsules; on inoculation of jelly with them a perfectly typical nail-growth developed. In the infiltrated parts of the lungs only very few or even no micrococci were found. It results from these experiments that guinea-pigs stand midway between mice and rabbits as regards their relation to our cultivations. About half the animals were refractory; the other half became affected with severe double pleurisy with abundant growth of micrococci with capsules, some also with pneumonia. Micrococci with capsules were only found in small numbers in the blood of two of the guinea-pigs which died. Swelling of the spleen was not made out. EXAMPLE OF EXPERIMENTS. 15th Sept. Material--cultivation of croupous pneumonia of 7th Sept. 3rd generation. 4 guinea-pigs. a. This animal is already very weak, 24 hours after injection, and has urgent dyspnoea; killed 27 hours after injection. Double pleurisy and pericarditis; about 5 ccm. of turbid, flocculent, purulent fluid on each side, co...
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