Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability? To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background ...
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Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability? To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from "neutral evolution". The final chapter studies the evolution of whole genomes by chromosomal inversions, reciprocal translocations, and genome duplication. Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies from the biology literature that illustrate the use of these results. This book is written for mathematicians and for biologists alike. We assume no previous knowledge of concepts from biology and only a basic knowledge of probability: a one semester undergraduate course and some familiarity with Markov chains and Poisson processes.
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Edition:
Softcover reprint of hardcover 2nd edition 2008
Publisher:
Springer-Verlag New York Inc.
Published:
12/6/2010 12: 00: 00 AM
Language:
English
Alibris ID:
17828594894
Shipping Options:
Standard Shipping: $4.57
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Seller's Description:
PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the UK.
Edition:
Softcover reprint of hardcover 2nd edition 2008
Publisher:
Springer-Verlag New York Inc.
Published:
12/6/2010 12: 00: 00 AM
Language:
English
Alibris ID:
17561811133
Shipping Options:
Standard Shipping: $4.57
Choose your shipping method in Checkout. Costs may vary based on destination.
Seller's Description:
PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the UK.
Choose your shipping method in Checkout. Costs may vary based on destination.
Seller's Description:
Very Good. Size: 9x6x1; 2nd edition. Very good paperback copy. Spine is uncreased, binding tight and sturdy. Previous owner's stickers markered out on title page, otherwise text is very good. Bottom edge has black circle, presumably a remainder mark. Shelfwear is minor. A reprint edition of high quality. Ships from Dinkytown in Minneapolis, Minnesota.
