This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1905 Excerpt: ...color is not obscured on colored impurities of the morphine. C. E. Carpari12 has worked out a method of estimating codeine in opium which promises moiv correct results that those obtained by Van der Wielen's process, this being the only previously published method. A specimen of powdered Smyrna opium yielded 1.12% and ...
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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1905 Excerpt: ...color is not obscured on colored impurities of the morphine. C. E. Carpari12 has worked out a method of estimating codeine in opium which promises moiv correct results that those obtained by Van der Wielen's process, this being the only previously published method. A specimen of powdered Smyrna opium yielded 1.12% and 1.33% codeine, which is about the percent, reported in the opium specimens examined by Van der Wielen and shows the statements found in text-book to the effect that opium contains 0.2 to 0.6% codeine, to be wrong. Pomegranate. Panchaud modified the method of the German Pharmacopoeia by substituting ammonia for sodium hydroxide, by omitting the addition of water before taking the aliquot portion, by substituting ether for the mixture of ether and chloroform and by titrating the alkaloids directly after a part of the ether has been distilled off. He directs to shake, vigorously and frequently, during one hour 12 Gin. powdered bark with 120 Gm. ether and 10 Cc. ammonia water. Then 100 Gin. (10 Gm. bark) of the clear ether solution are poured off, reduced to 25 Gm. by destination and titrated. G. Fromme18 approves of the substitution of ether for the chloroform-ether mixture and especially the omission of the water since the alkaloids are quite soluble in water. Experiments showed however that when the three-fourths of the ether is distilled off that not all the ammonia is expelled, while when the ether is all distilled off, much alkaloid was lost, the alkaloids of pomegranate being volatile. Fromme's experiments indicate that the drug contained some salt of ammonium or similar body which was estimated along with the alkaloid when sodium hydroxide was used to set free the alkaloid and the decanted ether solution titrated directly. If on the other ...
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