With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into ...
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With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist.
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Add this copy of Myelin Biology and Disorders, Two-Volume Set to cart. $109.44, new condition, Sold by discount_scientific_books rated 4.0 out of 5 stars, ships from Sterling Heights, MI, UNITED STATES, published 2003 by Academic Press.
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New. 0124395104. *** FREE UPGRADE to Courier/Priority Shipping Upon Request *** – – *** IN STOCK AND IMMEDIATELY AVAILABLE FOR SHIPMENT-FLAWLESS COPY, BRAND NEW, PRISTINE, NEVER OPENED 1600 pages; 9 pounds HARDCOVER--Virtually everything that has been learned about myelin biology has helped to resolve either a medical or a scientific mystery. Myelin Biology and Disorders, an extraordinary compilation of knowledge about myelin and myelin diseases, benefits from the intrinsic interest and importance of the topic no less than from the hard work of its contributing authors. The diseases of myelin, which are particularly well served by this two-volume book, include multiple sclerosis and acute inflammatory demyelinating polyneuropathy, as well as a host of hereditary disorders of central and peripheral myelin. The book is organized into sections that address the functional biology of myelin and glial cells, the development of glial cells, myelin genes and gene products, human diseases of myelin, and animal models of human disease. This structure seems counterintuitive at first but works brilliantly. It is remarkably easy to proceed, for example, from chapters on the development of glial cells to those concerning stem-cell--or progenitor-cell--transfer to promote remyelination and neural repair. As a consequence, Myelin Biology and Disorders can be useful both as a substantial reference work and as a selective "laminar" source that treats hereditary peripheral neuropathy as one complex subject. For example, 13 chapters on individual myelin proteins connect seamlessly, both backward to chapters on the functional biology of myelin and forward to those that address how the mutations in the genes that encode the proteins lead to hereditary neuropathies or dysmyelinating disorders of the central nervous system; from there, the chapters discuss animal models of the illnesses. This multiauthored, multieditor book comprises work by a dream team of researchers in the field of myelin, myelin-forming cells (oligodendrocytes and Schwann cells), and the medical problems associated with myelin damage. The roster of section editors (Bruce D. Trapp, Robert H. Miller, Hans Lassman, John W. Griffin, and Klaus-Armin Nave) conveys the quality of authorship, which is maintained throughout. The authors' commitment to this project is admirable; as one example, John Roder rewrote his chapter on myelin-associated glycoprotein to incorporate stunning and important new data showing that a molecule termed the Nogo receptor served also as an axonal receptor of myelin-associated glycoprotein. The book contains an implicit meditation on the scientific method, since myelin biology proceeded pari passu with methodologic advances. In myelin research, new techniques for tissue staining, microscopy, immunohistochemistry, cell and molecular biology, subcellular fractionation, cell-lineage studies and clonal analysis, genetic analysis, and the production of transgenic and knockout mice were all critical. Details about key techniques and their roles in the acquisition of new knowledge are nicely explained in relevant sections of the book and thereby provide a foundation for the nonspecialist reader. Given the particular importance of microscopy and immunohistochemistry in this area, it is gratifying to report that the illustrations are of near-uniform high quality. Of particular delight is that many illustrations map photomicrographs to aDJacent drawings, which clarify the implications of the data. The book begins with a lively historical review of the works and lives of Santiago Ramon y Cajal and Pio del Rio Hortega, giants on whose shoulders the field of myelin biology stands. Most of the basic-science chapters begin with a citation of their seminal research, with each reference being pertinent despite the passage of decades. Chapters on diseases of myelin also present antecedent work in full. This approach is particularly appropriate for the poorly...
