Table 1 Comparison of MIDD and immunoglobulinic amyloidosis MIDD Amyloidosis Presentation Multivisceral or predominant involvement of an organ (kidney) Underlying disease Monoclonal immunoproliferative disorders, mostly myeloma. Monoclonal bone marrow plasma cell populations without overt malignancy. Possibility of 'non-secretory' forms. Deposits by EM (Granular) non-organized Fibrillar (13 pleated sheets) Spectrum LCDD : L chains, most K, either AL-amyloidosis : fragments (?)* of or apparently enlarged, normal-sized normal ...
Read More
Table 1 Comparison of MIDD and immunoglobulinic amyloidosis MIDD Amyloidosis Presentation Multivisceral or predominant involvement of an organ (kidney) Underlying disease Monoclonal immunoproliferative disorders, mostly myeloma. Monoclonal bone marrow plasma cell populations without overt malignancy. Possibility of 'non-secretory' forms. Deposits by EM (Granular) non-organized Fibrillar (13 pleated sheets) Spectrum LCDD : L chains, most K, either AL-amyloidosis : fragments (?)* of or apparently enlarged, normal-sized normal-sized or apparently enlarged or short. Frequent glycosylation L chains most A. Frequent and polymeration. glycosylation.Abnormal susceptibility to proteolysis. LHCDD : associated H chains Cases with associated short H chains (short by biosynthesis by biosynthesis experiments. experiments). HCDD: short H chains. AH-amyloidosis : short H chains. L chain isotypy V K IV predominance. VAVI C A3predominance. V region mutations Yes Yes *Found in necropsy material; whether they exist in vivo is doubtful. 3 After Preud'homme et al. AL-amyloidosis). Therefore, we believe' that the term MIDD should be restricted to this pathological entity, whatever the Ig content of the deposits, light 4 5 ) or both (LHCDD ). However, the chains (LCDD), heavy chains (HCDD New York group used the denomination MIDD for both Randall's disease and immunoglobulinic amyloidosis'S". The two processes have many features in common (Table I) and they can be associated in the same patients.
Read Less
Add this copy of Monoclonal Gammopathies and the Kidney to cart. $80.30, like new condition, Sold by Fireside Bookshop rated 5.0 out of 5 stars, ships from Stroud, GLOUCESTERSHIRE, UNITED KINGDOM, published 2003 by Kluwer Academic Publishers.
Choose your shipping method in Checkout. Costs may vary based on destination.
Seller's Description:
Like New in No d/j as Published jacket. Size: 8vo-over 7¾"-9¾" tall; Type: Book The kidney involvement in monoclonal gammopathies is a fascinating field of research and of great concern to clinical practice. The book is divided into four parts. The first one is devoted to "the culprits" and includes contributions from leading investigators in B-cell proliferations, immunoglobulin synthesis, secretion and structure, light chain uptake and metabolism in the kidney. The second and third parts are devoted to "the victims": the tubule and the glomerulus. New insights into pathophysiology, clinical and histological features, treatment of renal lesions and therapy of B-cell proliferations are reported in myeloma cast nephropathy, Fanconi's syndrome, Randall-type monoclonal immunoglobulin deposition disease and non amyloid organized monoclonal immunoglobulin deposits. In the last part, immunoglobulinic amyloidosis is considered with a round table devoted to stem cell transplantation and new promising therapies in AL amyloidosis. 298pp.
Add this copy of Monoclonal Gammopathies and the Kidney to cart. $180.88, good condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Newport Coast, CA, UNITED STATES, published 2003 by Springer.
