This reference work, the result of a conference co-chaired with Nobel laureate Werner Arber, addresses the molecular strategies by which lineages of organisms respond to challenges and opportunities in their environment. It explores the notion that organisms have evolved the ability to modulate the rate, location and extent of genetic variation. Jumps in efficiency, made possible by development of novel efficient evolutionary strategies, could fuel rapid, saltatory expansion of species into novel niches as each innovation ...
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This reference work, the result of a conference co-chaired with Nobel laureate Werner Arber, addresses the molecular strategies by which lineages of organisms respond to challenges and opportunities in their environment. It explores the notion that organisms have evolved the ability to modulate the rate, location and extent of genetic variation. Jumps in efficiency, made possible by development of novel efficient evolutionary strategies, could fuel rapid, saltatory expansion of species into novel niches as each innovation evolves. An up-to-date assessment is provided on biochemical mechanisms available to modulate the rate of genetic change at specific sites within a genome, the induction in certain environments of enzymes with altered sequence-dependent recombination, mismatch repair and/or replication fidelity, and statistical evidence for nonrandom genetic events. This discussion of genomic strategies for evolution has profound implications for basic biology and evolutionary theory. The subjects explored are important ones in understanding inherited diseases, tumor progression and the challenges posed by pathogenic organisms.
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Good. Molecular Strategies in Biological Evolution (Annals of the New York Academy of Sciences) by Lynn Helena Caporale (Editor)--SOFTCOVER CONDITION GOOD SIGNED BY PREVIOUS OWNER-PUBLISHED BY THE NEW YORK ACADEMY OF SCIENCE COPYRIGHT 1999-434 PAGES Three. 300 p. Audience: Professional and scholarly; College/higher education. Molecular Strategies in Biological Evolution (Annals of the New York Academy of Sciences) by Lynn Helena Caporale (Editor)--SOFTCOVER CONDITION GOOD SIGNED BY PREVIOUS OWNER-PUBLISHED BY THE NEW YORK ACADEMY OF SCIENCE COPYRIGHT 1999-434 PAGES Three strategies of different quality contribute in parallel to the natural formation of genetic variants in bacteria: (1) small local alterations of DNA sequences; (2) recombinational reshuffling of segments of the genome; and (3) acquisition of DNA sequences by horizontal gene transfer. Key enzymes involved in these processes often act as variation generators by making use of structural flexibilities of biological macromolecules and of the effect of random encounter. In the theory of molecular evolution, genetic determinants of variation generators as well as of modulators of the frequency of genetic variation are defined as evolutionary genes.