Lee Hood set in motion a revolution that is personalizing medicine. His pioneering work on automated DNA sequencing gave scientists access to the genome, the code of life. In an accessible, fast-moving narrative, award-winning journalist Luke Timmerman tells the story of this forceful and flawed personality who transformed our world.
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Lee Hood set in motion a revolution that is personalizing medicine. His pioneering work on automated DNA sequencing gave scientists access to the genome, the code of life. In an accessible, fast-moving narrative, award-winning journalist Luke Timmerman tells the story of this forceful and flawed personality who transformed our world.
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Good in Good () jacket. [6], vi, 425, [1] pages. Illustrations. Includes Foreword by George Church. Also includes Preface, Acknowledgments, and Endnotes. Several pages wrinkled, some ink underlining to text. Some wear to dust jacket edges. Inscribed by the author on the front free endpaper. Inscription reads: Margaret, Keep up the good work connecting science & the patient community. --Luke Timmerman. Lee Hood, a son of the American West, was perhaps an unlikely candidate to transform biology. But with ferocious drive, he led a team at Caltech that developed the automated DNA sequencer, the tool that paved the way for the Human Genome Project. Luke Timmerman is a journalist, author, and entrepreneur. He is the founder of Timmerman Report, a biotech newsletter. The book was named one of the Top 100 Indie Books of 2017 by Kirkus Reviews. Forbes called it a "must read" popular science book. Timmerman is the founder and editor of Timmerman Report, a biotech industry newsletter. Timmerman has a bachelor's in journalism from the University of Wisconsin, and was awarded a Knight Science Journalism Fellowship at MIT. In 2015, Scientific American named him one of the 100 most influential people in biotech. Leroy "Lee" Edward Hood (born October 10, 1938) is an American biologist who has served on the faculties at the California Institute of Technology (Caltech) and the University of Washington. Hood has developed ground-breaking scientific instruments which made possible major advances in the biological sciences and the medical sciences. These include the first gas phase protein sequencer (1982), for determining the amino acids that make up a given protein; a DNA synthesizer (1983), to synthesize short sections of DNA; a peptide synthesizer (1984), to combine amino acids into longer peptides and short proteins; the first automated DNA sequencer (1986), to identify the order of nucleotides in DNA; ink-jet oligonucleotide technology for synthesizing DNA and nanostring technology for analyzing single molecules of DNA and RNA. The protein sequencer, DNA synthesizer, peptide synthesizer, and DNA sequencer were commercialized through Applied Biosystems, Inc. and the ink-jet technology was commercialized through Agilent Technologies. The automated DNA sequencer was an enabling technology for the Human Genome Project. The peptide synthesizer was used in the synthesis of the HIV protease by Stephen Kent and others, and the development of a protease inhibitor for AIDS treatment. Hood established the first cross-disciplinary biology department, the Department of Molecular Biotechnology (MBT), at the University of Washington in 1992, and co-founded the Institute for Systems Biology in 2000. Hood is credited with introducing the term "systems biology", and advocates for "P4 medicine", medicine that is "predictive, personalized, preventive, and participatory." Scientific American counted him among the 10 most influential people in the field of biotechnology in 2015 Derived from a Kirkus review: A debut biography examines a biologist whose DNA sequencing work paved the way for the Human Genome Project. Biotech journalist Timmerman met Leroy "Lee" Edward Hood as a Seattle Times reporter in 2001. Bill Gates had lured Hood to the University of Washington in 1991 with $12 million for a molecular biotechnology department, but in 1999 Hood resigned to found the Institute for Systems Biology. The book shrewdly opens with this turning point, then retreats to Hood's birth in Montana in 1938 and proceeds chronologically. A football quarterback and Westinghouse Science Talent Search finalist, Hood looked to professors to provide the positive example his alcoholic father didn't. Caltech hosted much of Hood's career, from undergraduate years-when he was president of the freshman class-to two decades on staff. While at Caltech, he co-wrote a biochemistry textbook and headed a cancer research center. "Never prone to self-doubt, " Hood was dedicated to innovation...
