"The process of developing the diverse blood cell repertoire from stem and progenitor cells termed hematopoiesis has been subject to considerable investigation. However, key steps in the complex process of hematopoiesis, including hematopoietic stem sell generation during embryogenesis, hematopoietic stem and progenitor cell expansion to accommodate physiological and pathological requirements, and mechanisms that ensure hematopoietic stem and progenitor cell phenotypic integrity, remain incompletely understood. Elucidating ...
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"The process of developing the diverse blood cell repertoire from stem and progenitor cells termed hematopoiesis has been subject to considerable investigation. However, key steps in the complex process of hematopoiesis, including hematopoietic stem sell generation during embryogenesis, hematopoietic stem and progenitor cell expansion to accommodate physiological and pathological requirements, and mechanisms that ensure hematopoietic stem and progenitor cell phenotypic integrity, remain incompletely understood. Elucidating these mechanisms will yield concepts that can be extrapolated to diverse biological realms, and given the vital importance of the hematopoietic system, future efforts will invariably lead to medical breakthroughs that advance human health. This issue of Current Topic in Developmental Biology reviews cutting-edge research on mechanistic and biological aspects of hematopoiesis. The initial chapters lay the groundwork for understanding the cellular origin of hematopoietic stem cells and the pivotal role of the microenvironment or "niche" in non-cell-autonomously regulating hematopoietic stem cell genesis and function. The next series of chapters probe into molecular mechanisms governing the development of hematopoietic stem and progenitor cells and for maintaining their unique phenotypes." -- Publisher's description
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