A doen???a inflamat???ria intestinal (DII) compreende um espectro de doen???as que se caracterizam por uma inflama??????o cr???nica do trato gastrointestinal sem uma causa ou pat???geno espec???fico. A gabapentina (GBP) ??? um f???rmaco anticonvulsivante, mas estudos pr???vios mostram que ela ??? eficiente em reduzir danos inflamat???rios g???stricos e diminuir o processo inflamat???rio agudo. Durante as colites h??? aumento de subst???ncias que atuam na via dos endocanabin???ides, que s???o importantes para a prote??????o ...
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A doen???a inflamat???ria intestinal (DII) compreende um espectro de doen???as que se caracterizam por uma inflama??????o cr???nica do trato gastrointestinal sem uma causa ou pat???geno espec???fico. A gabapentina (GBP) ??? um f???rmaco anticonvulsivante, mas estudos pr???vios mostram que ela ??? eficiente em reduzir danos inflamat???rios g???stricos e diminuir o processo inflamat???rio agudo. Durante as colites h??? aumento de subst???ncias que atuam na via dos endocanabin???ides, que s???o importantes para a prote??????o do c???lon durante o desenvolvimento do processo inflamat???rio intestinal. Assim, este trabalho objetiva analisar o efeito anti-inflamat???rio da GBP na colite induzida por ???cido ac???tico (AA) em camundongos e observar se este mecanismo de a??????o se d??? pela via farmacol???gica dos endocanabin???ides.Os resultados mostram que o AA foi eficaz em induzir a retocolite ulcerativa (RCU); que a GBP reduz a inflama??????o no c???lon causada pelo AA, por???m, seu efeito ??? provavelmente independente da via dos receptores endocanabin???ides, n???o sendo estes envolvidos na redu??????o do efeito inflamat???rio da RCU induzida experimentalmente, mostrando que esta via n???o representa uma alternativa terap???utica promissora para pacientes com RCU.
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PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the UK.
Choose your shipping method in Checkout. Costs may vary based on destination.
Seller's Description:
New. Text in Portuguese. Trade paperback (US). Glued binding. 84 p. Language: portuguese-In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
