The existence of endothelium-dependent hyperpolarization and endothelium-derived hyperpolarizing factor was firmly established during 1997 at an international symposium held near Paris, France. This further volume reinforces the concept that EDHF, as opposed to nitric oxide (NO), is of particular importance in smaller blood vessels and, in addition, underlines the multiplicity of other factors involved. Many candidate mediators are discussed, including some new, sometimes surprising ones and the actions of EDHF on vascular ...
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The existence of endothelium-dependent hyperpolarization and endothelium-derived hyperpolarizing factor was firmly established during 1997 at an international symposium held near Paris, France. This further volume reinforces the concept that EDHF, as opposed to nitric oxide (NO), is of particular importance in smaller blood vessels and, in addition, underlines the multiplicity of other factors involved. Many candidate mediators are discussed, including some new, sometimes surprising ones and the actions of EDHF on vascular smooth muscle cells are detailed, almost down to the molecular level. Further chapters enlarge our knowledge of the physiological and pathological roles of endothelium-dependent hyperpolarizations, and the book concludes with reports on the still limited but crucial knowledge of the contribution of EDHF in human blood vessels in health and disease. Endothelium-Dependent Hyperpolarizations will be of interest not only to physiologists and pharmacologists, puzzling over the complexity of interactions between the endothelium and the underlying smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases. Indeed understanding the nature and role of EDHF appears to be crucial in the quest for improved treatments for hypertension and other vascular disorders.
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