The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer , Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset. The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary ...
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The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer , Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset. The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer. This is the only book that presents a full analysis of the age of cancer onset. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For cancer biologists, population geneticists, evolutionary biologists, and demographers interested in aging, this book provides new insight into disease progression, the inheritance of predisposition to disease, and the evolutionary processes that have shaped organismal design.
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Seller's Description:
Very good. Ex-library. Trade paperback (US). Glued binding. 378 p. Contains: Illustrations, black & white. Princeton Evolutionary Biology, 1. Audience: General/trade. LCCN 2007007855 Type of material Book Personal name Frank, Steven A., 1957-Main title Dynamics of cancer: incidence, inheritance, and evolution / Steven A. Frank. Published/Created Princeton, N.J. : Princeton University Press, c2007. Description xi, 378 p. : ill.; 25 cm. ISBN 9780691133652 (cloth: alk. paper) 0691133654 (cloth: alk. paper) 9780691133669 (pbk. : alk. paper) 0691133662 (pbk. : alk. paper) LC classification RC268.5. F63 2007 Contents Age of cancer incidence--Multistage progression--History of theories--Progression dynamics--Theory I--Theory II--Genetics of progression--Carcinogens--Aging--Inheritance--Stem cells: tissue renewal--Stem cells: population genetics--Cell lineage history. Subjects Carcinogenesis. Cancer--Age factors. Cancer--Genetic aspects. Cancer--Epidemiology. Neoplasms--etiology. Age of Onset. Gene Expression Regulation, Neoplastic. Genetic Predisposition to Disease. Mutagenesis. Stem Cells. Notes Includes bibliographical references (p. [335]-359) and indexes. Additional formats Also available in electronic form as viewed 10 August 2007. Series Princeton series in evolutionary biology Dewey class no. 616.99/4071 NLM class no. 2007 I-452 QZ 202 F828d 2007 National bib no. GBA747336 National bib agency no. 101300029 013772707 Other system no. (OCoLC)ocm85498596 (OCoLC)85498596
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Book is in very good condition and may include minimal underlining highlighting. The book can also include From the library of labels. May not contain miscellaneous items toys dvds etc. We offer 100% money back guarantee and 24 7 customer service.
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Fine. Trade paperback (US). Glued binding. 400 p. Contains: Illustrations, black & white. Princeton Evolutionary Biology, 1. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
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This is an ex-library book and may have the usual library/used-book markings inside. This book has soft covers. In fair condition, suitable as a study copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item, 650grams, ISBN: 9780691133669.
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New. Trade paperback (US). Glued binding. 400 p. Contains: Illustrations, black & white. Princeton Evolutionary Biology, 1. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
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PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the UK.
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PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the UK.
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Seller's Description:
Fine. Trade paperback (US). Glued binding. 400 p. Contains: Illustrations, black & white. Princeton Evolutionary Biology, 1. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
