This third edition has been updated to cover all aspects of chiral drugs from the academic, governmental, industrial, and clinical perspectives. New topics include the use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery, how stereochemistry impacts decisions made in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) stages of drug discovery, and issues faced during the final stages of the drug development process. It also discusses the impact of ...
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This third edition has been updated to cover all aspects of chiral drugs from the academic, governmental, industrial, and clinical perspectives. New topics include the use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery, how stereochemistry impacts decisions made in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) stages of drug discovery, and issues faced during the final stages of the drug development process. It also discusses the impact of International Conference on Harmonisation (ICH) on the use of single isomer drugs, chiral switches, molecular chiral recognition, and legal perspectives.
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