Statistics in Practice A new series of practical books outlining the use of statistical techniques in a wide range of application areas: Human and Biological Sciences Earth and Environmental Sciences Industry, Commerce and Finance Cross-over Trials in Clinical Research Stephen Senn Biometrics, Medical Department, CIBA-Geigy Ltd, Basle, Switzerland Cross-over Trials in Clinical Research provides a practical introduction to this important tool within the pharmaceutical industry. Aimed at guiding practitioners in the ...
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Statistics in Practice A new series of practical books outlining the use of statistical techniques in a wide range of application areas: Human and Biological Sciences Earth and Environmental Sciences Industry, Commerce and Finance Cross-over Trials in Clinical Research Stephen Senn Biometrics, Medical Department, CIBA-Geigy Ltd, Basle, Switzerland Cross-over Trials in Clinical Research provides a practical introduction to this important tool within the pharmaceutical industry. Aimed at guiding practitioners in the methods of using cross-over designs efficiently, this book presents a fresh insight into how such trials may be designed and analysed. Key features of this comprehensive treatment are: A focus on the two-period AB/BA design, including the most up-to-date developments in this topic. Important aspects of special design--graphical and tabular presentation of trials, robust approaches to analysis, and practical issues in planning. Direct relevance to drug development with an approach rooted firmly in biology and pharmacokinetics rather than stressing the mathematical aspects. All techniques included are discussed and illustrated in detail with many practical examples drawn from the author's wide-ranging experience. This book will prove an invaluable reference to all statisticians and researchers in the pharmaceutical industry. It will also appeal to physicians involved in clinical research.
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